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Principal Scientist, Flow Cytometry
Location:
Collegeville, PA
Description:
We are looking for a highly motivated, flexible and experienced scientist to join the Cellular Biomarkers Flow Cytometry team within Biomarker & Bioanalytical Platforms in the Precision Medicine department located in Upper Providence, US.The team is responsible for the development and validation of complex multi-parameter flow cytometry panels and subsequent application of these panels to clinical trial sample analysis. The deep immunophenotyping data generated by these biomarker panels helps us to evaluate disease heterogeneity, drug-target engagement, drug mechanism of action and patient responses.The successful candidate will have a deep understanding of immunology and will act as a flow cytometry technical expert, supporting high parameter deep immunophenotyping of immune cell subsets as well as receptor occupancy endpoints. This is a lab-based role and will include all aspects of flow cytometry method development and optimization, validation and sample analysis for clinical studies across the entire GSK portfolio.This role will be responsible for completion of all aspects of assay workflow including reagent selection, sample preparation, sample acquisition, data analysis, interpretation and presentation. In addition, this role will ensure all work is conducted in compliance with GCP regulations including adherence to the appropriate SOPs. In this role you will Generate high quality data to support clinical studies by spectral flow cytometry (Cytek Aurora) Conduct and oversee all aspects of method development, troubleshooting, validation and sample analysis for clinical studies Handle human biological samples and perform experimental work in accordance with GCP regulations, safety assessments and data integrity guidelines Be responsible for delivery of robust, high-quality data packages Deliver, interpret and communicate complex scientific data to project/program teams within agreed timelines Contribute to biomarker strategy and capital equipment discussions Help lead efforts to investigate novel cytometry and data analysis platforms and embed them within the organization Manage multiple projects concurrently Function well in a team and possess a good balance of creative and analytical skills Be willing to develop and train others as required Why you? Basic Qualifications: Bachelors degree and six or more years' relevant experience or PhD with two or more years' experience Two or more years' experience with immunological enabling phenotyping of multiple cell lineages Two or more years' experience with flow cytometry and in design and execution of 16+ colour flow cytometry panels Two or more years' of laboratory experience and expertise working with a variety of sample types including whole blood, PBMC, cell lines and single-cell suspensions from tissues Preferred Qualifications & Skills: If you have the following characteristics, it would be a plus: A good understanding of the drug development process Experience in design and execution of 22+ colour flow cytometry panels In-depth knowledge of various immune subsets In-depth knowledge of receptor occupancy assays Hands on practical experience with the Cytek Aurora Strong laboratory experience and understanding of clinical and non-clinical flow cytometry biomarker assay development, validation and implementation Hands on experience with high-dimensional data analysis ( e.g. tSNE, UMAP, CITRUS, FlowSOM) Experience of technology transfer of flow cytometry assays to Contract Research Organizations Experience of writing SOPs and other regulated documents Willingness to work with human samples infected with blood borne pathogens including HIV and HBV, etc. Considerable experience in the use of flow cytometry analysis software (OMIQ preferred) Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor, and operational excellence even when flexing between multiple projects Attention to detail, good communication and documentation skills Ability to work independently to tight deadlines with a proactive attitude Be a highly motivated team player with the ability to interact effectively within a multi-disciplinary team Ability to problem solve and troubleshoot Good judgment and decision making, especially for prioritizing multiple requests Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why Us? GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-XXXX (US Toll Free) or +1 801 567 XXXX (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.PDN-9bb55058-e35a-4233-9825-acba29a45a3d
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More About this Listing: Principal Scientist, Flow Cytometry
Principal Scientist, Flow Cytometry is a Science & Pharmaceutical Scientist Job at GSK located in Collegeville PA. Find other listings like Principal Scientist, Flow Cytometry by searching Oodle for Science & Pharmaceutical Scientist Jobs.
Principal Scientist, Flow Cytometry is a Science & Pharmaceutical Scientist Job at GSK located in Collegeville PA. Find other listings like Principal Scientist, Flow Cytometry by searching Oodle for Science & Pharmaceutical Scientist Jobs.